*1Ajuru, Gospel, 2Nwosu, Dennis Chimezie, 3Ifenkwe, John Chimerenka, 4Sibe, Lebari
1Department of Biomedical Sciences, School of Science Laboratory Technology, University of Port Harcourt, Rivers State, Nigeria.
2Department of Chemical Pathology, Imo State University, Imo State, Nigeria.
3Department of Chemical Pathology, Health Check Integrated Services, 193 Chief Melford Okilo Way, Yenagoa, Bayelsa State, Nigeria.
4Department of Biochemistry/Chemistry Technology, School of Science Laboratory Technology, University of Port Harcourt, Rivers State, Nigeria.
*Corresponding Author: Ajuru, Gospel; condolencefh@gmail.com, Tel.: +2348033366252
Abstract
This study was carried out to determine the effect of antiretroviral therapy on some lipid parameters of HIV seropositive individuals in Rivers State, Nigeria. A total of 300 HIV patients were recruited in this study, aged 20-70 years. They were classified into three groups; Group 1 was made up of HIV sero-Positive infected individuals on highly antiretroviral therapy as the test subjects. Group 2 was HIV sero-Positive infected individual but not on highly active antiretroviral therapy as control 1. Group 3 was HIV sero-negative individual as control 2. Ethical approval for the study and informed consent from the participants were obtained. Results showed that there was statistically significant increase (P<0.005) in CHOL F-= 20.847, P=0.000, TG F=8.872, P=0.000, HDL-C F= 66.695, P=0.000 of test subject and control I compared to control II. No statistically significant increase (P>0.005) in LDL-C F=1.801, P=0.167 compared to control I and control II. Also there were statistically significant increase (P<0.05) in CHOL-F=2.774, P=0.000, TG F=8.606, P=0.000, HDL-C F=19.172, P=0.000, LDL-C F=672.745, P=0.000, of the test subject and control I compared to control II in relation to sex (male and female). There was statistically significant increase (P<0.05) in TG F=2.897, P=0.001 and LDL.C F=17.765, P=0.000, of the test subjects and control I compared to control II in relation to age groups. There was no statistically significant increase (P>0.05) in CHOL F=3.894, P=0.053, and HDL-C F=0.5020, P=0.912 of the test subjects and control I compared to control II in relations to age groups. Based on duration of therapy from 0-2years, there were no statistically significant increase (P>0.05) in TG F=0.545, P=0.786, and HDL-C levels F=7.630, P=0.275. However, a statistically significant increase (P>0.05) was observed in CHOL F=0.000, P=0.000 and HDL-C levels F=0.000, P=0.000. For 2-5 years there were no significant increase (P<0.05) in TG, CHOl, HDL-C, and LDL-C. For 5-10 years, there were no statistically significant increase (P>0.05) in CHOL, TG, HDL-C, TG, HDL-C and LDL-C. This study demonstrated that long term administration of HAART to HIV infected positive subjects could lead to metabolic disorder such as dyslipidaemia which could predispose the patient to high risk of conorary heart disease.
Keyword: Anti-retroviral drugs, Highly antiretroviral therapy, HIV sero-negative, HIV seropositive, Lipid parameters
